The second literature is transcriptomic
Retatrutide (research code LY3437943) is a triple agonist that binds GIP, GLP-1, and glucagon simultaneously, setting it apart from the dual GIP/GLP-1 agonist tirzepatide and the GLP-1 mono-agonist semaglutide
They compare patients initiating treatment in a given month to those who initiate 12 months later in a one-year follow-up design and 60 months later in a five-year follow-up design, allowing them to control for underlying time trends and baseline health differences
Use caution in a patient with a history of angioedema or anaphylaxis with another GLP-1 receptor agonist Acute Gallbladder Disease: Acute events of gallbladder disease such as cholelithiasis or cholecystitis have been reported in GLP-1 receptor agonist trials and postmarketing
Some estimates suggest that if just 10% of eligible employees started GLP-1 therapy, employer health costs could increase by 15% to 25%
Tirzepatides Weight Loss Results Tirzepatide has shown even more remarkable weight loss outcomes