REDEFINE 2 specifically tested CagriSema in adults with type 2 diabetes and found it produced 15.7% weight loss and an HbA1c reduction of 1.8 percentage points over 68 weeks
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In addition, nausea is believed to result mainly from central mechanisms, in which activation of GLP-1R neurons in the area postrema plays a predominant role rather than from delayed gastric emptying alone 46
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