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It activates one of the body's master regulators of metabolism, an enzyme called AMP kinase, triggering some of the same benefits that fasting and exercise provide to our cells

2014 Feb;28(2):514-9

Published data from the Phase 3b STRIDE trial reported that Ozempic 1 mg via SC injection once weekly improved maximum walking distance by 13% relative to placebo after 52 weeks

It works by mimicking ghrelin , the hunger hormone, and binding to the growth hormone secretagogue receptor (GHS-R1a) without increasing cortisol or prolactin levels like older peptides such as GHRP-6 or GHRP-2

Sorensen M, Sanz A, Gmez J, Pamplona R, Portero-Otn M, Gredilla R, Barja G: Effects of fasting on oxidative stress in rat liver mitochondria

Both GLP1-RAs and SGLT2is contribute to weight loss through different mechanisms