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High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited

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We propose this is because Gdh2 is still present and has a high affinity for the enzymatic deamination of glutamate into -ketoglutarate

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