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Inhibition of HMG-CoA leads to reduction of intracellular cholesterol in hepatocytes, which will activate the SCAP-SREBP-2 mechanism leading to an increase in the gene expression for low density lipoprotein (LDL) receptor (LDLR)
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E.DongH.BergmanM
Without a substantial change in UK medicines law or the development of a fully proven and licensed non-injectable alternative for malabsorption conditions like PA, the injection will remain a Prescription-Only Medicine
May Support Fat Metabolism Lipotropic nutrients are associated with fat transport and metabolism
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