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guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g

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Pediatric research confirmed infants have significant BAT deposits (critical for temperature regulation before shivering develops), but this tissue was assumed to disappear with age

Brenneisen, P

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When exposure continues or regulatory systems remain unstable, symptoms can become multi-system and long-lasting rather than temporary