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As a 2025 narrative review in PubMed confirming BPC-157 promotes angiogenesis, accelerates tendon and bone healing, and protects gastrointestinal lining across multiple animal models notes, the current evidence base is robust in preclinical settings with no approved human trials completed to date

BPC-157 oral can often be safely combined with other therapies including digestive enzymes, probiotics, gut-healing supplements like L-glutamine, elimination diet protocols, and conventional gastric medications when properly coordinated

When combined, these overlapping side effect profiles may worsen GI tolerability, particularly during the dose escalation phase when tirzepatide GI effects are already at their peak