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Personal or first-degree relative(s) history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma

Carnitine acetyltransferase (CrAT) can act as safety valve to catalyze the reversible transfer of acetyl groups between acetyl-CoA and acetylcarnitine, promoting the combination of excess acyl groups with carnitine, increasing the membrane permeability of these products and thus removing them from the mitochondria, allowing acylcarnitine to be formed in the mitochondrial matrix and exported to the plasma [7]

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However, it remains important to consider that GLP-1 receptor agonists may be limited by unfavorable side effects, especially in the context of PD