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Important safety considerations include a boxed warning for thyroid C-cell tumors, contraindication in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and precautions regarding pregnancy (not recommended), reduced oral contraceptive effectiveness, and risks of pancreatitis, gallbladder disease, and acute kidney injury

In vivo, it is secreted by the L-cells of the small intestine in response to nutrient ingestion

Enfermedad gastrointestinal severa : Pacientes con gastroparesia u otros trastornos graves de motilidad gastrointestinal no son candidatos ideales para tirzepatida, ya que puede empeorar estos trastornos

Patients with persistent symptoms should think about stopping their medication [10]

This makes Tirzepatide useful for studying receptor signaling, cell communication, and differences between laboratory models

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