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However, in people with type 2 diabetes, GIP does not contribute at all to the total insulin secretion effect of the combination while the insulinotropic effect of GLP-1 is only slightly impaired

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Compounded medications are available in different doses, strengths, and forms

While current treatments largely focus on symptom relief, agents such as Wnt pathway modulators (e.g., lorecivivint), ADAMTS-5 inhibitors, and nerve growth factor (NGF) antagonists like tanezumab are under investigation for their potential to alter disease progression (Jiang et al., 2021