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Lofqvist C, Willett KL, Aspegren O, Smith AC, Aderman CM, Connor KM, et al

These systems can deliver far more of a drug to the brain than the aerosolized or atomized solutions currently available

Gene expression profiling revealed distinct apoptotic pathways: low-dose exposure triggers apoptosis through cellular stress responses, while high-dose exposure primarily activates it via direct DNA damage (160)

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We suggest glutathione is one such endogenous source, as further impairing glutamate liberation from the cycle diminishes synaptic activity induced by MeAIB, while increasing glutamate availability can rescues the impairment by MeAIB

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