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Research suggests that epithalon may increase the functional activity of skin fibroblasts, normalizing intracellular matrix hemostasis [20]
This is attributed to its increase in fibroblast proliferation [3, 22]
Maturation skews macrophage polarization from M1 to M2 (interleukin-4 [IL-4], interleukin-10 [IL-10], IL-12, Arginase 1 [Arg-1]
The collagen synthesis mechanisms involve MAPK/ERK pathway activation, which upregulates collagen gene expression at the genetic level
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