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Indeed, GIPR agonism can blunt the nauseating effects of GLP-1R agonists in humans ( + population ( + neurons in the rat hindbrain are located primarily in both inhibitory and excitatory neurons in addition to some expression in oligodendrocytes ( + neurons are necessary for the food intake reducing effects of GIPR agonists and dual incretin co-agonists ( + neurons are necessary for the food intake reducing effects of GLP-1R agonists ( + neurons in the AP ( Figure 4 )

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Reuters reported more gastrointestinal side effects, more treatment discontinuations, and an average increase in pulse rate

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For severe nausea, antiemetic medications may be prescribed, though this should be discussed with the healthcare provider