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Results The first cohort included 36 082 GLP-1 receptor agonist users (median follow-up 1.3 years) and 234 028 DPP-4 inhibitor users (median follow-up 1.7 years)

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Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial

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Because it engages all three, retatrutide is often described as a triple agonist. For comparison, tirzepatide is a dual agonist (GLP-1 and GIP) and semaglutide is a single agonist (GLP-1)

Among various modeling techniques, PBPK modeling appears to be particularly promising