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AEs that occurred in 10% or more of apitegromab-treated participants with 5% or higher frequency than in placebo-treated participants included nausea, fatigue and headache

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SNAC is an acylated amino acid designed to improve the oral bioavailability of parenteral drugs that was extensively tested on cyanocobalamin and macromolecular drugs such as heparin and insulin [16,17]

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The observation of reticulocytosis which usually occurs between the third and tenth day of therapy confirms the diagnosis of vitamin B12 deficiency