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NAC may be supportive in APD by: Helping replenish glutathione, which plays a role in regulating immune responses Reducing oxidative stress that can worsen mast cell activation and inflammation Supporting overall inflammatory balance, particularly during hormonally driven immune flares Some research also suggests NAC may influence mast cellmediated pathways indirectly 13 , which may be relevant in conditions where histamine release contributes to symptoms

Additionally, women should use two forms of birth control (such as birth control pills and male latex condoms) or avoid sexual intercourse during treatment

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10.1016/j.bbi.2021.11.023 124 TilgH.AdolphT

Accessed 07/26/2015