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Ozempic has a boxed warning for risk of thyroid cancer, and metformin has a boxed warning for risk of lactic acidosis

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All studies that met the inclusion for the SLR were eligible for inclusion in the ITC

The two drugs are also competing head to head in obesity, where Novo Nordisk sells its drug as Wegovy and Lilly's is called Zepbound

Semaglutide is not a quick fix, and the best results often come from combining medical treatment with lifestyle improvement

rotate: Lamiophlomis rotate SM: Shanzhiside methylester MAPK: p38 mitogen-activated protein kinase DPN: Diabetic peripheral neuropathy MCU: Mitochondrial calcium uniporter UCP3: Uncoupling protein 3 DRP1: Dynamin-related protein 1 STZ: Streptozotocin ERK: Extracellular signal-regulated kinase MMP-2: Matrix metalloproteinases-2 MMP-9: Matrix metalloproteinases-9 NLRP3: NOD-like receptor protein 3 AGEs: Advanced glycation end products CSA: Cross-sectional area CM: Chronic migraine TNC: Trigeminal nucleus caudalis CGRP: Calcitonin gene-related peptide ICP: Intracranial pressure CSF: Cerebrospinal fluid IIH: Idiopathic intracranial hypertension References Zheng Z, Zong Y, Ma Y, Tian Y, Pang Y, Zhang C, Gao J (2024) Glucagon-like peptide-1 receptor: mechanisms and advances in therapy