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In a retrospective study of trends in prescribing AOM from 2004 to 2018, phentermine was the most widely prescribed weight loss medication (50% in 2018), followed by naltrexone-bupropion (19%) and liraglutide 3.0 mg (13%)
Importantly this was based on two preclinical efficacy studies in the SOD1 G93A mouse which did not account for the now well described pitfalls in experimental design 10 , which have led to new guidelines for preclinical research
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