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This metabolic dysregulation is defined by systemically reduced levels of metabolites such as amino acids and fatty acids, leading to reduced TCA cycle activity and oxidative phosphorylation, which may ultimately be a major contributor to neuropsychiatric symptoms associated with reduced energy, such as fatigue and other cognitive impairments [43, 62]
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Carnitine also plays a role in metabolic regulation, detoxification, and cell membrane stabilization.[ref] This article covers: Mitochondrial energy production from long-chain fatty acids How carnitine is synthesized, including genes involved Effect on weight, mental health, immune response, and bone health Genetic changes and inborn errors of metabolism Lifehacks and solutions for optimizing carnitine levels Carnitine in Mitochondrial Energy Production: The Carnitine Shuttle Carnitine plays a specific role in mitochondrial energy production
The CCA for the remaining meta-analyses was 8.93%, indicating a moderate level of overlap
Peddada, S
