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10.1021/acs.molpharmaceut.9b00114 108 McCoyM

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[3] The doses used in these tendon studies typically ranged from 10 to 200 micrograms per kilogram of body weight, administered once daily, which when extrapolated to a 75-kilogram human would suggest a working range of approximately 200 to 500 micrograms per day

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Thiamine, a crucial co-factor in the TCA cycle and glycolysis, is partially produced by gut bacteria like Bacteroides , which are often reduced in ME/CFS patients [139]

doi: 10.1001/archinte.164.12.1275 107 TsubotaKTodaIYagiYOgawaYOnoMYoshinoK