It can also be impaired by MTHFR genetic variations
R., Witkow, S., Greenberg, I., Golan, R., Fraser, D., Bolotin, A., Vardi, H., Tangi-Rozental, O., Zuk-Ramot, R., Sarusi, B., Brickner, D., Schwartz, Z., Sheiner, E., Marko, R., Katorza, E., Thiery, J., Fiedler, G
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Similarly, the in vivo administration of an equimolar dose of DTT (40 mm) instead of NAC to TNBS+ethanol rats failed to either increase GSH levels and protect against injury, suggesting that the beneficial effect of NAC was due to its role as a GSH precursor
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