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Unprotonated ions permeate the lipid-bilayer and accumulate inside the vesicle until [AH + ] in /[AH + ] out = [H + ] in /[H + ] out , where AH + is the compounds protonate form

Xiaflex is used only when the original curve is greater than 30 degrees since thats when major insurers will provide reimbursement as the drug is very expensive

Neuropsychopharmacology 25 , 455467 (2001)

Thats what makes them one of the most exciting and fastest-growing areas in regenerative and anti-aging medicine