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Immediate medical review is necessary for these signs, and therapy should be paused until a clinician evaluates the cause

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Neuhouser, M.L., Rock, C.L., Eldrige, A.L., Kristal, A.R., Patterson, R.E., Cooper, D.A., Neumark-Sztainer, D., Cheskin, L.J., Thornquist, M.D., 2001

Alcohol consumption: Regular or heavy drinking depletes glutathione and increases oxidative stress, counteracting supplementation benefits

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Glutathione and glutathione-S-transferases in the normal and diseased research-subject liver