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ZhouSXueJShanJHongYZhuWNieZet alGut-flora-dependent metabolite Trimethylamine-N-oxide promotes atherosclerosis-associated inflammation responses by indirect ROS stimulation and signaling involving AMPK and SIRT1

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It also slows gastric emptying, which contributes to improved glycaemic control and weight reduction, particularly in the early stages of treatment, though this effect may attenuate over time

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Diabetes, Obesity, and Metabolism, 25 (4), 975-984

Normally, when you eat, GLP-1 is released naturally and has the following actions: Signals the stomach to release food slowly Stimulates the pancreas to stop releasing glucagon, and start releasing insulin to prepare for a spike in blood sugar (Eventually) travels to the brain and acts on several areas involved in appetite regulation, shutting down the desire for food These are powerful effects, but they are tempered by the fact that GLP-1 doesnt stick around for very long