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15.4 Administration to Pediatric Patients Safety and efficacy in pediatric populations are not fully established

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Moreover, Wnt signaling can be modulated by oxidative stress, with ROS promoting -catenin degradation

Within the TME, these nanoparticles can be reduced to Cu by GSH, which subsequently reacts with hydrogen peroxide via a Fenton-like reaction to generate hydroxyl radicals, ultimately inducing ferroptosis in PDAC cells [51]