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Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons

GHK-Cu reduced inflammatory cell infiltration into lung tissue, increased superoxide dismutase activity (bolstering antioxidant defense in the lungs), and decreased both TNF-alpha and IL-6 production

The model predicted that for 10-hour-long toxicologically relevant doxorubicin (50 M) simulations, the duration of the exposure is more important than concentration with respect to overwhelming glutathione metabolism