tirzepatide in mash for with Liver Fibrosis Tirzepatide hits two receptors. Semaglutide

The Journal of Nutrition, 134(3), 489492

But look carefully at what HIMS did and did not say

There is a risk of dehydration and acute kidney injury, particularly if experiencing severe gastrointestinal side effects

Metformin contraindications include type 1 diabetes, kidney dysfunction, congestive heart failure that requires drug treatment, hypersensitivity to metformin, acute or chronic metabolic acidosis, and impaired liver function

However, RAS inhibition has not yet been found to prevent kidney disease among those with type 1 diabetes, normal blood pressure and without albuminuria, and also does not prevent the progression of histological changes associated with DKD at the early stage of disease [22]

A significant decrease in plasma total glutathione (tGSH) reported in four studies from the one research group in children with autistic disorder compared to controls [4648, 50] have been confirmed by another two research groups with respect to autistic disorder [81, 82] as well as study of low functioning children with autism spectrum disorders [85] (Figure 7)