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Materials and methods Mouse studies All animal procedures were approved by the Institutional Animal Care and Use Committee of the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences

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cell proliferation and differentiation: MAPKK (MEK) 1/2 [S221/S225], ERK1 [T185/Y187], ERK2 [T185/Y187], ERK1/2 [T202/Y204]

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