Choi, Y
The EMPA-KIDNEY, Collaborative G, Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR, Preiss D, Judge P, Mayne KJ, Ng SYA, Sammons E, Zhu D, Hill M, Stevens W, Wallendszus K, Brenner S, Cheung AK, Liu ZH, Li J, Hooi LS, Liu W, Kadowaki T, Nangaku M, Levin A, Cherney D, Maggioni AP, Pontremoli R, Deo R, Goto S, Rossello X, Tuttle KR, Steubl D, Petrini M, Massey D, Eilbracht J, Brueckmann M, Landray MJ, Baigent C, Haynes R
Monitor appropriately
For a complete side-by-side, see the tirzepatide reconstitution chart
Originally containing the important cytosolic CXC motif, CD4 then underwent rapid evolution at two distinct protein-protein interaction sites in D1 and D2, both bearing important Cys residues
It was originally developed as a chemically modified ligand designed to stimulate the release of growth hormone (GH) while exerting minimal influence on other endocrine axes