Drugs with a high V D have diffused more into the surrounding tissues and so may be more lipophilic
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IMO or Intestinal Methanogen Overgrowth involves methane-producing archaea, causing constipation and bloating
A stable oral form allows researchers to study its effects directly within the GI tract and investigate its systemic absorption more reliably, something that is very difficult with the acid-sensitive acetate form
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[1] [3] If left untreated, some of these changes can become permanent
