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Hormone replacement therapy combined with GLP-1 medications can be synergistic, particularly for perimenopausal and menopausal women or for men with low testosterone

Oral semaglutide is FDA-approved for people with type 2 diabetes, but it has also shown promise in those with obesity, even without diabetes

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For researchers using IGF-1 LR3 as a tool to study these pathways, the practical advantage is that sustained receptor activation enables longer time-course studies of pathway dynamics

For example, excessive amounts of Vitamin D can lead to Vitamin D toxicity