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This is known as a false positive
NNMT acts as a primary metabolic gatekeeper, predominantly active in fat tissue and liver cells, where it methylates nicotinamide (NAM) using S-adenosyl-L-methionine (SAM) as a methyl donor
blood pressure may decrease alongside weight loss, and any cardiovascular effects should be interpreted in the context of overall trial data rather than assumed to be adverse
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Expect consistent but not rapid weight loss
2022) Recommended for the hypovolemic subtype of POTS and those with low blood pressure
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