ROS are generated as byproducts after electron leaking at complex I and III (Hernndez et al., 1993
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Activation of mitochondrial 2-Oxoglutarate dehydrogenase by Cocarboxylase in human lung adenocarcinoma cells A549 is p53/p21-dependent and impairs cellular redox state, mimicking the cisplatin action
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Critically, a study has shown that the levels of GSH, a key antioxidant, are significantly reduced in the AD brain and that the extent of this depletion correlates positively with the severity of cognitive impairment (43)