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It is estimated that up to 40% of the population carries at least one variant of the MTHFR gene (such as the C677T polymorphism), which significantly reduces the enzyme's ability to convert dietary folate into its active form, L-5-MTHF

However, neurodegenerative disease mechanisms differ substantially between animal models and human diseases, and premature clinical use based solely on animal data could expose patients to unknown risks without established benefits

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Several factors can trigger sulfur burps beyond dietary choices