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People using these GLP-1 meds start with smaller doses and gradually increase to higher amounts over time
So far, the company has only reported phase 3 results from the SURPASS-PEDS trial of its injectable therapy tirzepatide in this population, demonstrating HbA1c reductions of around 2.2% alongside meaningful decreases in BMI
FTO rs9939609 and MC4R rs17782313 variants also relate to appetite regulation and energy expenditure pathways
GI side effects, especially nausea, tend to peak in the first few days after each injection
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