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In summary, fixed ratio combination of GLP-1RA and basal insulin are potentially helpful tools for the treatment of patients with T2DM as a result of its favorable safety and efficacy profile, particularly in patients who are overweight and uncontrolled on OADs or basal insulin
Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LC, Demeter SH, et al
Never discontinue prescribed medications without medical guidance, as abrupt cessation may worsen glycemic control or cause weight regain
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Given the mechanism of action of oral semaglutide [56], which includes delayed gastric emptying [24], a number of studies have assessed the impact of oral semaglutide/SNAC on exposure to other commonly administered oral drugs [71,72,73]
Ethical concerns about distribution question whether using semaglutide only for weight loss limits those needing it for diabetes treatment
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