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found that early natural menopause and smoking had a synergistic effect [46], and even after age matching, we confirmed this synergistic relationship

95% CI, 1.12-1.49)

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Clinical Evidence Strength: What the Trials Actually Show MK-677 Human Trials Eight weeks of MK-677 at 25 mg daily in obese men increased bone resorption markers (CTX +26%, urinary hydroxyproline/creatinine ratio +23%) and elevated IGFBP-5 by 43 to 44%