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Acylcarnitine is more stable and less reactive than acyl-CoA and is an ideal form for storing activated acyl groups that can be transferred to CoA and provide a direct source of energy via FAO

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Although the aforementioned studies have demonstrated that targeting the necroptosis pathway is a viable strategy in AML, the clinical relevance of the RIPK1/RIPK3/MLKL axis remains unclear (135137)