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f , i , Proposed fragmentation pathways of flavan-3,3,4-triol ( 4 ) for fragments observed in negative ( f ) and positive ( i ) ion ESI-MS

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safe in long-term use for approved indications.[38][64] Common Side Effects : Injection site reactions (24-37%), arthralgia, headache.[65][66] Absolute Contraindications : Active malignancy, pregnancy, hypersensitivity.[67][68] Relative Contraindications : Diabetes (monitor glucose), severe renal/hepatic impairment.[69][70] Monitoring Parameters : VAT, lipids, glucose, IGF-1 every 3 months.[71][72] Regulatory Status FDA Classification : Approved as Egrifta for HIV lipodystrophy