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Studies conducted with Caco-2 cells in a laboratory setting, utilizing inhibitors of transporter proteins and knockout methods, have pinpointed the main transporter proteins responsible for metformin as the organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), serotonin transporter (SERT), and high-affinity choline transporter (CHT) (Han et al., 2015)

That is helpful, but it creates a new challenge

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Because peptides can target specific tissues or pathways, they offer a more precise approach than broad treatments like steroids or NSAIDs

IgE and igG antibodies as regulators of mast cell and basophil functions in food allergy