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Hinson JA

After correction for multiple comparisons, correlations between glutathione, glutamate, NAA, creatine, and myo-inositol in the ACC remained significant

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Nutrient Deficiencies (Building Blocks Missing) Glutathione synthesis requires specific nutrients: Cysteine : From dietary protein (whey, eggs, poultry)-rate-limiting Glycine : Often deficient in modern diets (need 10-15g/day, most get 3-5g) Selenium : Cofactor for glutathione peroxidase (GPx) , the enzyme that recycles GSSG back to GSH B vitamins (B6, B9, B12): Required for methylation and sulfur metabolism Vitamin C : Recycles oxidized glutathione Deficiency in any of these impairs glutathione production or recycling [5]

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22 This ordered progression, initiated from a defined focus of ferroptotic stress, strongly supports a propagative process rather than simultaneous co-injury, implying directional information flow across a cell population