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What the data shows: REDEFINE-1 (obesity without diabetes): 22.7% average weight loss vs 2.3% placebo | 91.9% achieved 5% weight loss REDEFINE-2 (type 2 diabetes + obesity): 14-16% weight loss sustained over 68 weeks Consistent GLP-1 class safety profile with potential for fewer GI side effects due to amylin co-agonism What this means for practice: This isn't just another weight-loss drugit's addressing the mechanistic gap in dual-pathway therapy
Another effect of decreased GI motility is reflux, or GERD
Effect of weekly subcutaneous semaglutide vs
Morphine suppressed flinches in both phases
174,175 Several oncogenic mechanisms, such as the transcription factor HIF-1, PI3K/Akt/mTOR pathway and c-Myc, upregulate genes encoding glucose transporters and glycolytic proteins, including GLUT1, GLUT3, and lactate dehydrogenase (LDH)
All this information will help them determine the most suitable course of medication management
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