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Total testosterone: a core driver of energy, lean mass, and fat distribution
Reduction in Risk Across Fourteen Obesity-Related Cancers A large observational study presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2025, involving more than 170,000 patients with diabetes and obesity, found that GLP-1 receptor agonists were associated with a modest but statistically meaningful reduction in the incidence of 14 obesity-related cancers , with colorectal cancer demonstrating particularly favourable outcomes when compared to patients receiving DPP-4 inhibitors
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As bias can be time point-specific (Klein Herenbrink et al., 2016), we also used the FRET biosensor T Epac VV (Klarenbeek et al., 2011) to obtain real-time readouts of cAMP signalling (Supplementary Figure 1E)
Age and Overall Health: Older adults or those with underlying health conditions may experience different weight loss rates compared to younger, healthier individuals
Supplementary material Acknowledgements Disclaimer Provided under licence Explanation and source of recommendations Appendix 2
