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Retrograde Mitochondrial-Nuclear Signaling One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs

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That means food leaves the stomach more slowly, which can increase fullness and reduce the speed at which hunger returns

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Generally, when combined, we see a 3-5 fold increase in growth hormone release over ipamorelin alone