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SARMs were first developed in the early 1990s after Dalton and Miller, who discovered that aryl propionamides with structural similarities to bicalutamide and hydroxyflutamide could activate AR-dependent transcriptional activity provided the early lead for the development of diaryl propionamide class of SARMs

Incorporating research-based findings into effective intervention renders a potential frontier

For example: Remove inflammatory foods and obvious food triggers

Other approaches, such as oral GSH precursors or intravenous GSH, are promising, but they are invasive and not practical for home use

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