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Tirzepatide trial shows additional 21.1% weight loss following intensive lifestyle intervention A phase 3 clinical trial evaluating the injectable prescription medication tirzepatide, showed an additional 21.1% weight loss after intensive lifestyle intervention in adults with obesity or who were overweight with weight-related comorbidities, excluding Type 2 diabetes

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Tirzepatide, a dual GIP and GLP-1 receptor agonist marketed as Mounjaro and Zepbound, demonstrates substantial weight reduction in clinical trials, yet most patients experience periods where weight loss slows or temporarily stalls