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2 Activation of the GHR and GHR-stimulated signal transduction pathways has been comprehensively reviewed elsewhere, and we refer the reader to recent reviews for a more detailed description of GHR-mediated signaling
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These conditions include cardiovascular disease (such as coronary artery disease, stroke, life-threatening arrhythmias, congestive heart failure, or untreated hypertension), advanced arteriosclerosis, hyperthyroidism, glaucoma, psychiatric agitation or psychosis, recent or concurrent MAOI therapy (within 14 days), history of drug abuse, pregnancy, breastfeeding, pediatric patients under 16, and concurrent use of other weight-loss medications
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