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Decisions should be individualized based on product source, patient condition, clinical response, and safety assessment
PMCID: PMC10836305 Gandolfi JV, Di Bernardo APA, Chanes DAV, Martin DF, Joles VB, Amendola CP, Sanches LC, Ciorlia GL, Lobo SM (2020) The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial
Patch berberine has none
Some of the RCTs detected a reduction in skin fragility in hospitalized elderly patients after nursing procedures and improved healing after laser procedures
Rare adverse events or idiosyncratic reactions could be missed entirely with groups this small
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