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Providing a treatment option that is proven to lower this cardiovascular risk is a major advance for public health. The FDAs decision is largely based on data from the SELECT trial, which included more than 17,000 overweight or obese patients with a baseline age of 45 years old

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GLP-1 receptor agonists including semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound), and a growing pipeline of new entrants are being prescribed to tens of millions of Americans for weight loss and diabetes management, and they are fundamentally altering how, when, and how much people eat

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PMID 24003936