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Nonetheless, in primary care, an acute visual loss demands an urgent referral to the ophthalmologist

SVZ, sub-ventricular zone

For these, a larger individual may require a dose closer to the advanced range to achieve the same systemic concentration

Patients experiencing symptoms potentially attributable to thyroid dysfunction (unexplained fatigue, significant cold intolerance, hair loss, severe constipation) should be evaluated with thyroid function testing, but routine thyroid monitoring is not required for patients without risk factors or symptoms

PD-L1 expression is associated with ALK positivity and STAT3 activation, but not outcome in patients with systemic anaplastic large cell lymphoma